The Best Depression Products

Saturday, February 4th

2023 Depression Product Reviews

St. John's Wort

• Cost: $23.99 for 120 capsules

St. John's Wort is named after one of the most common homeopathic ingredients in natural antidepressant supplements. This product works to boost your mood and calm anxiety as well as depression. The makers of St. John's Wort boast that this supplement is as effective as prescription antidepressants, but without any of the side effects.

Clinical Studies

The bold claim that St. John's Wort will work as well as prescribed medication is based on clinical studies that concluded that the most effective dose to achieve maximum results with this supplement is 900 mg per day. Each St. John's Wort capsule contains 450 mg, so when taking this product twice per day, you should have relief from symptoms of depression and anxiety for 24 hours.

Very Affordable, Plus Free Shipping

St. John's Wort works best when taken two times daily, preferably one capsule each in the morning and at night. Each bottle contains 120 capsules, so it should last up to 2 months. For $23.99/bottle, this is one of the most affordable depression relief options online. You'll also get free shipping on your first order.

Not Just The Wort

The ingredients listed for St. John's Wort are St. John's Wort, vegetable capsule, and rice flour. The product description does say that the supplement contains 0.3% (2.7mg) of Hypericin per serving. This is a compound that increases levels of serotonin in the brain, a hormone that helps you feel happiness. It also helps with seasonal affective disorder, promotes a good night's sleep, and reduces symptoms of menopause.

30 Money-back Guarantee

If St. John's Wort doesn't work for you, you can send it back for a full refund under the 30-day unconditional money-back guarantee.

Positive Customer Reviews

Maybe the best part of this product is the high ratings from customers. Many people say they have been on prescribed antidepressants and have the same relief from their depression with St. John's Wort without the negative side effects. Many say their appetite is coming back, they are more energetic, and they feel a shift in their mood quickly after taking the capsules.

Highest Rating

The effectiveness and fast results that people feel when taking St. John's Wort is hard to beat. The price point for a 2-month supply of the supplement is also very affordable. We like that St. John's Wort has so few ingredients, comes with a money-back guarantee, and doesn't have side effects to be concerned about. This supplement has earned our highest rating for depression relief products.

Joy-Filled

• Cost: $29.95 for 60 capsules

Joy-Filled is a plant-based supplement that targets anxiety as well as depression. This herbal product is meant to act as an antidepressant and relax the mind, boost your mood, and relieve stress. Joy-Filled is made by Happy Healthy Hippie, a company that believes in using the nutrients that our earth provides for us. Their other products target areas and issues such as hormone balance, lactation, sleep, skin, hair, nails, muscles, joints, and more.

Save With Auto-delivery

Each bottle of Joy-Filled comes with 60 veggie capsules. For best results, 2 capsules should be taken daily with food. This means each bottle lasts about a month. The cost for Joy-Filled is $29.95 unless you decide to subscribe and save by having it auto-delivered every 2 weeks to 6 months depending on your desired schedule. By subscribing, you'll save 10% on each bottle.

7 Powerful Herbs

There are 7 powerful herbs used in Joy-Filled. Happy Healthy Hippie lets customers know they don't believe in "fairy dusting", where a tiny, ineffective amount of each herb is included in a product. The herbs and their doses include:

• Gotu Kola Herb (300 mg): Binds to the neurotransmitter, GABA, to help maintain a stable mood.
• Rhodiola Root (200 mg): Contains bioactive chemicals that support a healthy response to stress.
• St. John's Wort Herb (200 mg): Increase serotonin and dopamine in the brain to help with a positive outlook.
• Ashwagandha Root (200 mg): Reduces stress by supporting adrenal functions.
• Lemon Balm Leaf Extract (200 mg): Increases the production of GABA to promote calmness.
• Ginkgo Leaf (100 mg): Counteracts the effects of adrenaline, resulting in less stress for the body and mind.
• Eleuthero Root (100 mg): Helps the body better utilize energy and improves circulation to the brain for mental clarity.

Other ingredients listed are hypromellose (capsule), microcrystalline cellulose, and magnesium stearate.

Negative Interactions

Happy Healthy Hippie warns that if you take Joy-Filled, it will negatively interact with some prescribed anti-anxiety and antidepressant medications. It also should not be taken if you are taking vitamins to increase serotonin. The best thing to do before using Joy-Filled is to consult with your physician to make sure it is safe for you.

60 Day Return Window

If you don't feel that Joy-Filled met your needs, Happy Healthy Hippie will let you return it within 60 days for a full refund. There isn't a specified timeframe for when Joy-Filled should start making you feel a difference, so it is best to use it for a few weeks before deciding whether or not it works for you.

Positive Customer Reviews

There are over 5,000 customers who have left reviews about their experience using Joy-Filled. We were pleased to see that these reviews averaged 4.4 out of 5 stars as reported by the retailer. Many people say that Joy-Filled has changed their life and given them the ability to move forward with a healthier, happier outlook. If your physician says this is a safe supplement for you, we highly recommend using Joy-Filled. At an affordable price and with so many positive reviews, this is a great option for those experiencing depression.

Bio-Cheer

• Cost: $39.95 for 180 tablets

Bio-Cheer is manufactured and sold by Native Remedies, a company that makes homeopathic products to help with digestion, stress and anxiety, sexual health, thyroid support, pain relief, and many other issues. None of their products contain artificial colors, preservatives or flavors, and are never tested on animals. While not specifically marketed for depression relief, Bio-Cheer is formulated to support nervous system balance, lift a doleful mood, and encourage a more cheerful outlook.

Boost In Wellness

Each bottle of Bio-Cheer contains 180 tablets that should last approximately 30 days. According to Native Remedies, some customers feel a boost in wellness within days, while for others it may take longer - response times to most natural remedies depend on lifestyle, individual makeup, and diet. Reportedly, Bio-Cheer is safe to take with other medications and supplements.

10 Homeopathic Ingredients

Bio-Cheer is formulated to be 100% homeopathic. There are 10 ingredients in the product, all with descriptions letting customers know what they are for rather than explaining exactly how they work. The ingredients include:

• Anacardium 30C: helps with a low mood and poor self-esteem
• Graphites 30C: recommended for those with indecision, self-doubt, and shyness
• Lilium 30C: recommended for emotional and physical fatigue
• Sepia 30C: helps those with self-doubt, shyness, and those who seem to be coping but are sad under the surface
• Staphysag 30C: prescribed for people who bottle up their emotions, especially anger
• Inactive Ingredients: Acacia Gum, Distilled Water, Lactose, Magnesium Stearate, Sucrose

Chewed Or Dissolved

Bio-Cheer tablets can be chewed or dissolved in the mouth. For children, it may be a good idea to crush the tablets and combine them with soft food or in a drink. For adults and children 13+, it is recommended that they take 2 tablets 3 times daily. For children 2-12, they should take 1 tablet 3 times daily. Native Remedies suggests using Bio-Cheer 10 minutes after a meal, or 30 minutes after brushing teeth. Pregnant or breastfeeding women should consult a health professional before use.

Buy 2, Get 1 Free

Each bottle of Bio-Cheer is $39.95. If you choose to take advantage of Native Remedies' auto-delivery service, you get 15% off of each bottle. You can have a new bottle delivered every 4, 6, 8, or 12 weeks. Native Remedies also has a Buy 2 Get 1 Free discount for Bio-Cheer which is a great way to save money if you plan to buy this supplement in bulk. Or, if there's another condition you'd like to handle, you can mix-and-match all products with the "B2G1 Free" designation.

Money-back Guarantee

All of the products sold by Native Remedies are backed by an unconditional money-back guarantee. You can try their products for 30 days and return within 1 year for a complete refund if you are unsatisfied.

Good Company Reputation

At the time of this evaluation, there were no reviews for Bio-Cheer on the Native Remedies website. However, the company itself has good feedback from customers who have bought their products. Since Bio-Cheer is a natural, non-addictive product that can be taken with other medications, it seems low risk to at least try it out for 30 days. Their money-back guarantee is extremely generous, so you really have nothing to lose. We recommend giving Bio-Cheer a try to boost your mood!

Enlifta

• Cost: $39.99 for 30 tablets

Enlifta is a natural antidepressant created by a board certified medical doctor (though his name and credentials are not listed). It is manufactured in the USA, but has not been evaluated by the FDA. Enlifta is meant for people who feel overly tired, are often in a sad or blue mood, have an unusual lack of interest in hobbies, are easily emotional, have a change in appetite, or are experiencing feelings of worthlessness.

Up To 8 Weeks

There are 30 tablets in each Enlifta bottle. Consumers are instructed to take one tablet with food for 12 days and then evaluate how they feel. If they feel their mood is boosted, then they can continue with one tablet per day, otherwise they may want to increase the dosage up to a maximum of 3 tablets per day. It may take up to 8 weeks for a full response to Enlifta, at which point you should be able to tell if this supplement is working for you or not.

Full Refund If Unsatisfied

The cost for Enlifta is $39.99/bottle. This should last about 30 days unless you increase your dosage. If you're unsatisfied with Enlifta after you've used up a bottle or two, you can get a full refund, no questions asked.

7 Main Ingredients

There are only 7 main ingredients in Enlifta including Vitamin D (20 mcg), Folate (335 mcg), Vitamin B (5 mcg), Zinc (5 mg), St. John's Wort Extract (450 mg), Rhodiola root (100 mg), and 5-HTP (100 mg). Other ingredients include microcrystalline cellulose, stearic acid, dicalcium phosphate, croscarmellose sodium, magnesium stearate, silica and pharmaceutical glaze. Four of these main ingredients are key to the mood-boosting effects of Enlifta:

• 5-HTP: Naturally occurring amino acid that helps build serotonin and melatonin, two neurotransmitters that are involved in feelings of happiness and an improved mood.
• Folic Acid: Vitamin necessary for creating the substances in the brain that make you happy.
• St. John's Wort: Most widely used herb for mood support. Promotes tranquility and a healthy emotional outlook.
• Rhodiola Rosea: Believed to support neurotransmitters in the brain needed to feel happiness.

Not Meant For Everyone

Although Enlifta is a natural product, it is not meant for everyone. It is warned that this product should not be given to women who are or may become pregnant, nursing mothers, anyone diagnosed with bipolar or schizophrenia, those having surgery within 2 weeks of taking Enlifta, anyone who has received an organ transplant, people diagnosed with HIV or an autoimmune disease, those with Parkinson's disease, and any individuals currently taking or within 2 weeks of taking an MAOI.

Many Positive Customer Reviews

Most people who have used Enlifta report that it has had a noticeable effect on their mood and overall quality of life. People say it helps them feel like their "old self" and get some energy back. It is not uncommon to read that customers tried Enlifta before using a prescription medication and were happy to report that they didn't need the prescription after all. This is definitely not going to be the case with everyone, but it could be extremely beneficial for some.

Success Comes At A Price

Our only disappointments with Enlifta are the price as well as the long list of people who can't use the product. If you're buying 1-3 bottles ($40 - $120) a month and plan to take Enlifta for a long time, this might be a pricey option. We also feel like a lot of people on the "do not take" list could benefit from an antidepressant supplement. For example, pregnant or nursing women are prone to depression, but they wouldn't be able to take Enlifta. Otherwise, if you are generally healthy and able to spend the money, Enlifta has a high level of success and we recommend giving it a try.

MindSoothe

• Cost: $39.95 for 60 capsules or 2 fl oz

MindSoothe is the second depression product in our review sold by Native Remedies, a company owned by Silver Star Brands, Inc. Native Remedies has a long line of homeopathic supplements they sell online to help with digestion, allergies, focus, anxiety, sexual health, nervous system, pain relief, joint support, and more. MindSoothe is a natural supplement for people ages 12 and older to help with a healthy attitude and emotional wellness.

Relieve The Symptoms

MindSoothe is not necessarily formulated to cure depression, but it does help relieve most of the symptoms that depressed people experience. These include:

• Low self-esteem
• Excessive tearfulness
• Disturbed sleep patterns
• Loss of libido
• Fatigue and lack of motivation
• Irritability and anger
• Loss of appetite

Get The Discounts

You can purchase MindSoothe either in liquid or capsule form. Regardless of how you purchase it, the price is $39.95. If you choose to use Native Remedies' auto-delivery service and have MindSoothe delivered every 4, 6, 8, or 12 weeks, you'll save 15% on each bottle. Also, for first-time subscribers, Native Remedies will give you 40% off your order, plus free shipping if you sign up for their email list.

Each Bottle Lasts 10 Days

Adult customers who buy MindSoothe in capsule form are instructed to take 2 capsules 3 times daily for 4-6 weeks. After 4-6 weeks, the dosage should be reduced to 2 capsules 2 times daily. Anyone younger than 18 years of age should adjust their dosage according to the instructions on MindSoothe's product page. Each bottle comes with 60 capsules, so a single bottle would only last 10 days. After 4-6 weeks of this, the dosage is reduced so that each bottle would last 15 days.

Drops Last 20-30 Days

If you're taking MindSoothe in liquid form, the drops should be mixed with ¼ cup of water to drink or put directly in your mouth. Adults are instructed to take 1 mL 3 times daily for 4-6 weeks. After 4-6 weeks, the dosage is reduced to 1 mL 2 times daily. Consumers 18 years and younger also have different dosage recommendations based on their age. For adults, the liquid MindSoothe drops would last 20-30 days.

Just 2 Ingredients

MindSoothe's formula is 100% herbal and only contains two ingredients. The first is certified organic St. John's Wort Herb, which is used for balancing your mood and maintaining equilibrium. The other ingredient is Wild Crafted Passion Flower Herb, which is said to deal with imbalances in the nervous system including nervous tension, insomnia, and stress headaches.

100% Money-back Guarantee

There is no specific timeframe that results are guaranteed when taking MindSoothe. However, if you use it for a few weeks or months without a noticeable change in your depression symptoms, Native Remedies has a 100% money-back guarantee. You can return your products within one year and get a full refund.

Not For Everyone

MindSoothe has over 55 customer reviews on its product page, but many of them are filtered to only show the best ones. Be aware that this supplement isn't for everyone. If you are taking antidepressant medication, pregnant or breastfeeding, have bipolar, or uncontrolled high blood pressure, you should not take MindSoothe.

Cost Can Be Overwhelming

The cost of using MindSoothe long-term could feel overwhelming if you are buying 1-3 bottles per month. At $39.95 a bottle, this adds up quickly, making this potentially one of the pricier options among depression relief supplements. However, Native Remedies is a reliable company that many customers buy from frequently and have great success with. Although MindSoothe is not our first pick for depression relief, it is not a bad homeopathic option for those who can afford it.

TransZen

• Cost: $44.99 for 120 capsules

TransZen is made by a company called EntheoZen, who also makes a probiotic supplement to boost your mood. TransZen is a natural supplement to help relieve stress associated with depression and anxiety. The combination of ingredients increases dopamine levels, serotonin, and GABA. EthneoZen's goal is to help customers enjoy life again by balancing their brain chemistry, and finding peace and motivation.

17 Ingredients

Since low moods can be caused by nutritional deficiencies, the blend of 17 ingredients in TransZen is meant to help your body heal and resume optimal function. The ingredients include Vitamin B6, Vitamin B12, Niacin, Riboflavin, 5HTP, Mucuna pruriens extract, L-theanine, Magnesium (as citrate), Spirulina, Ashwagandha extract, Turmeric extract, Passion Flower (whole herb), Lemon Balm extract, Blueberry extract, Black Pepper extract. Other ingredients include a vegetarian capsule and rice flour. What you won't find in TransZen are the controversial ingredients magnesium stearate or silicone dioxide, which are commonly found in other supplements.

Each Bottle Lasts 1-2 Months

There are 120 capsules in a bottle of TransZen. 2-4 capsules should be taken daily with or without food, so the supplement will last anywhere from 1-2 months. Since the optimal time of day to take TransZen and the dosage varies for everyone, customers are instructed to listen to their bodies and do what feels best for them.

Higher End Of Prices

Each bottle of TransZen is $44.99, which is on the higher end of depression relief supplements. However, if you buy multiples of any EntheoZen products, you can save between 10% and 15%. A discount code is also listed on TransZen's product page if you plan to buy more than one bottle at a time, which will bring the cost down a bit.

Not For Everyone

If you are on any SSRI or MAOI antidepressant medications, you should not take TransZen. Additionally, pregnant and nursing women should consult their medical doctor before using this supplement to ensure that there will be no side effects for them or their baby.

30 Day Return Policy

If you find that TransZen doesn't meet your expectations, you can return it within 30 days for your money back. We found that many customers reported better moods and the ability to manage their depression and anxiety with TransZen and healthy lifestyle habits. Others felt it made no difference or said the short-term relief (only a few hours) wasn't worth the price. Everyone's body is different, so it makes sense that TransZen won't work 100% of the time for each user. However, overall the majority of customers felt benefits from this supplement.

Proceed With Caution

We would like to see some more specific information about the age groups that are safe to use TransZen, since that isn't mentioned. It leaves us unsure if children or teenagers could use the supplement, or if it is just for adults. This is also one of the more expensive options for depression relief supplements, so it may not be the best choice for everyone. But, TransZen is still a product to consider when looking for anxiety and depression relief, especially if you've tried less-expensive options and haven't gotten the results you hoped for.

Mood Boost

• Cost: $29.99/60-capsule bottle

Mood Boost is a product made and sold by LES Labs, a company founded in 2009 that sells a variety of nutritional supplements. Mood Boost is formulated to reduce stress and anxiety, promote a positive mood, and improve sleep quality. The FDA has not evaluated Mood Boost and it is not intended to cure depression, but rather help with aspects of your lifestyle that may be affected by anxiety and depression.

Buy 1 Get 1 Free

A bottle of Mood Boost comes with 60 capsules. It is recommended that one or two capsules are taken daily as recommended by a physician, so your bottle should last 1-2 months. Mood Boost costs $29.99 and at the time of this review, LES Labs was offering a buy 1, get 1 free promotion. That is a steal of a deal! If you choose to buy additional Mood Boost supplements or one of the many other products sold by LES Labs and end up spending $40 or more, you'll get free 2-day shipping.

13 Ingredients

There are 13 ingredients in Mood Boost that you can view on the product page. The five main ingredients are:

• 5-HTP (75 mg): A mood enhancer effective for anxiety and stress.
• L-Tyrosine (150 mg): An amino acid that helps reduce stress and anxiety that occurs during long periods of sleep deprivation.
• L-Theanine (50 mg): Reduces mental and physical stress to boost mood and increase mental focus.
• Passion Flower (75 mg): Reduces anxiety and nervousness to improve sleep
• Ashwagandha (100 mg): Supports mental health, anxiety levels, and overall quality of life.

May Not Be As Potent

We noticed that the amount of a few ingredients are lower than in some competing depression supplements. This could be concerning because it may mean that although these important ingredients are found in Mood Boost, they may not be potent enough to have a strong effect.

Consult With Your Physician

Pregnant or nursing women, people on antidepressant medication or who have a liver disorder should consult with their physician before taking Mood Boost. If negative side effects occur, you should stop using this supplement.

Returns Accepted - But Read The Fine Print

If you are unhappy with the results of Mood Boost and decide to discontinue use of the supplement, you can return one opened bottle per order and any unopened bottle within 60 days for a refund. Each sealed bottle returned will be charged a $5 restocking fee and customers are responsible for return shipping costs.

Try A Higher-rated Product

Overall, Mood Boost seems like a decent option for relieving symptoms of depression. There are a few thousand reviews on LES Labs' website for the product, but they are all 5-stars, which usually means they aren't all reliable. Mood Boost is one of the best priced supplements on the market for depression relief, but that could be because of the low potency of the ingredients they use. Mood Boost doesn't seem like a bad option, but it doesn't outshine the competition either. We recommend trying a higher-rated product before using Mood Boost.

MoodBrite

• Cost: $22.95 for 60 tablets

MoodBrite is a natural, temporary relief from sadness, low motivation, fatigue, social avoidance, and hyper-sensitivity. It is a supplement sold by HelloLife, a company that also sells products to help with hyperactivity, the respiratory system, nerve pain, restless legs, and joint pain. HelloLife has a customer base that is very happy with their customer service, product line, and fast delivery.

Relief For Symptoms

If you're wondering if MoodBrite might be a supplement that could help you, there are long lists of symptoms on the product page that MoodBrite addresses. Some of these include feeling discouraged, neglecting responsibilities, operating in a mental fog, isolating from friends and family, struggling in school, feeling irritable, and more.

19 Homeopathic Ingredients

The 19 homeopathic ingredients in MoodBrite are supposed to strengthen the body's natural defenses to fight against the symptoms that people with depression and anxiety face. The ingredients are all listed on the product page, but it was disappointing that the amount of each one was not listed. We like to see transparency in all aspects of a product's formulation to know whether or not a supplement is strong enough to make a difference for the user.

Recommended Dosage

The recommended dosage of MoodBrite is based on weight. For those who weigh 30-50 pounds, 1/2 tablet should be taken twice daily. For children, the tablets could be crushed and sprinkled onto the tongue. If you weigh 50+ pounds, take 1 tablet twice daily and chew or dissolve the tablets in your mouth. Each bottle of MoodBrite comes with 60 tablets, which is about a month's supply.

Safe For Adults And Children

Tablets melt quickly in your mouth. It is safe for adults as well as children and teens. It is said to be non-habit forming, doesn't cause weight gain, won't reduce libido or cause drowsiness, and does not include any GMOs.

100% Satsifaction Guarantee

The cost for a bottle of MoodBrite is $22.95. If you aren't 100% satisfied with MoodBrite, you can get a full refund if you request a return authorization and ship back your products (up to two opened bottles and any number of unopened bottles) within 60 days.

Only 1 Customer Review

Although HelloLife has over 540 reviews around the internet that are mostly positive, MoodBrite specifically only has one on their website. The customer gave MoodBrite 4/5 stars because they say they have felt better after using it, but they aren't sure if it is because of positive life changes or the product. We would like to see more feedback from customers before giving MoodBrite a high recommendation.

Disappointing Lack Of Information

We are also disappointed about the lack of information about the ingredients in MoodBrite. This is an indication that some ingredients are used in such small quantities that they may have insignificant effects.

Better Choices Elsewhere

There are more wordy details on this website than some competitors, but not all of it is useful. The online shopping experience at HelloLife and lack of some key information for MoodBrite has landed them on the lower end of our recommendations for depression-relief supplements.